Can radiotherapy treat Alzheimer’s disease?

Eliminating amyloid-β plaque is a beneficial treatment strategy for patients with Alzheimer’s disease (AD), helping to delay progression of the disease. However, the use of drugs to destroy amyloid-β is limited by the blood-brain barrier (BBB). Now, research in laboratory mice has shown that external-beam radiation can produce a significant reduction in AD-associated amyloid-β plaques, with a subsequent improvement in cognitive function.