Combination controversies: checkpoint inhibition alone or in combination for the treatment of melanoma?

The immune checkpoint inhibitors ipilimumab, nivolumab, and pembrolizumab have dramatically improved outcomes for patients with metastatic melanoma; however, not all patients benefit from monotherapy with these agents. To address this issue, complementary combinations of immunotherapy are increasingly being explored as a strategy to improve outcomes, including checkpoint inhibition plus radiotherapy.
Cancer Network