Radiotherapy and vaccination can magnify effects of immunotherapy

By combining local radiotherapy and anti-cancer vaccines with checkpoint inhibitors, researchers from the University of Chicago, working with mice, were able to increase the response rate for these new immunotherapy agents. The findings, published in the June 13, 2016 issue of the journal Oncotarget, showed this sequence of treatments could open up unresponsive pancreatic cancers to immune cell infiltration, often leading to immunologic control of tumour growth.